论文标题：Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours

期刊：Nature Communications

作者：Yordi J. van de Vegte, M. Abdullah Said et al.

发表时间：2020/04/21

DOI：10.1038/s41467-020-15553-w

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《自然-通讯》本周发表的一篇论文Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours 报道了与特定久坐休闲活动相关的遗传位点。根据研究开展的遗传和观察分析，作者发现，增加看电视的时间可能是冠心病（CAD）的一个风险因素。

久坐不动行为的全基因组和参与者基因分析结果。来源：van de Vegte et.al

为了认识遗传学对久坐行为的可能影响，以及久坐行为是否是冠心病的一个潜在致病风险，荷兰格罗宁根大学医学中心的Niek Verweij和同事开展了全基因组关联研究。作者利用英国生物样本库（UK Biobank）中42,2218名欧洲血统个体（年龄从40岁到69岁）的数据，鉴定出了169个与久坐休闲活动相关的遗传位点（145个与看电视相关、36个与电脑使用相关、4个与开车相关，有16个位点在以上两种久坐性状之间出现了重叠）。在一项孟德尔随机化分析中，作者预计，每天看电视的时间增加1.5小时（在平均数2.8小时的基础上）是一个会增加冠心病风险的因素。不过，作者并没有发现电脑使用或开车与冠心病之间的联系。

作者提醒称，久坐行为的相关信息来自研究对象的主观测算，且研究中未纳入与他们职业相关的久坐行为。作者指出，需开展进一步研究将分析范围扩大至所有久坐行为、身体活动和睡眠行为。

摘要：

Leisure sedentary behaviours are associated with increased risk of cardiovascular disease, but whether this relationship is causal is unknown. The aim of this study is to identify genetic determinants associated with leisure sedentary behaviours and to estimate the potential causal effect on coronary artery disease (CAD). Genome wide association analyses of leisure television watching, leisure computer use and driving behaviour in the UK Biobank identify 145, 36 and 4 genetic loci (P < 1×10−8), respectively. High genetic correlations are observed between sedentary behaviours and neurological traits, including education and body mass index (BMI). Two-sample Mendelian randomization (MR) analysis estimates a causal effect between 1.5 hour increase in television watching and CAD (OR 1.44, 95%CI 1.25–1.66, P = 5.63 × 10−07), that is partially independent of education and BMI in multivariable MR analyses. This study finds independent observational and genetic support for the hypothesis that increased sedentary behaviour by leisure television watching is a risk factor for CAD.

（来源：科学网）