Wechat: https://mp.weixin.qq.com/s/WGhasxOj8AGP7zURBWCVlw

Mary Regina Boland, Marc S. Kraus, Eddie Dziuk & Anna R. Gelzer

doi:10.1038/s41598-018-25199-w

计算模型；数据挖掘；转化研究

Published:

17 May 2018

The canine heart is a robust physiological model for the human heart. Recently, birth month associations have been reported and replicated in humans using clinical health records. While animals respond readily to their environment in the wild, a systematic investigation of birth season dependencies among pets and specifically canines remains lacking. We obtained data from the Orthopedic Foundation of Animals on 129,778 canines representing 253 distinct breeds. Among canines that were not predisposed to cardiovascular disease, a clear birth season relationship is observed with peak risk occurring in June-August. Our findings indicate that acquired cardiovascular disease among canines, especially those that are not predisposed to cardiovascular disease, appears birth season dependent. The relative risk of cardiovascular disease for canines not predisposed to cardiovascular disease was as high as 1.47 among July pups. The overall adjusted odds ratio, when mixed breeds were excluded, for the birth season effect was 1.02 (95% CI: 1.002, 1.047, p = 0.032) after adjusting for breed and genetic cardiovascular predisposition effects. Studying birth season effects in model organisms can help to elucidate potential mechanisms behind the reported associations.

根据《科学报告》发表的一项研究Cardiovascular Disease Risk Varies by Birth Month in Canines，一只狗出生的月份可能会影响其患心血管疾病的风险。

美国宾夕法尼亚大学的Mary Regina Boland及其同事分析了253种不同品种的129,778只狗的心血管数据后发现，在没有心血管疾病遗传易感性的品种中，6月至8月出生的狗与其它月份出生的狗相比，前者患心血管疾病的风险更高。但是，出生季节似乎不会在这方面影响原本就具有心血管疾病遗传易感性的狗。

利用算法处理狗狗的心脏报告并且对每只狗的整体心脏健康状况作分类。

Boland et al.

作者认为，由于出生季节与心血管疾病之间的关系在不具有遗传易感性的狗中更为明显，因此这种效应可能是由于环境因素造成的。其中一个因素可能是选择性育种，即易患心血管疾病的狗比不易患病的狗受到更为严密的监测。作者认为也可能存在遗传因素的影响，遗传因素使得不易患心血管疾病的狗更易受到出生季节相关的不利环境影响。

狗的心脏被认为是有效的人类心脏生理模型，因为这两个物种具有相似的心血管系统，而且由于他们生活在一起，所以也暴露在相似的环境压力下。因此，研究人员认为这些发现可能有助于理解人类心血管疾病与其出生季节之间的关系。（来源：科学网）