|
|
| FMD | 膜性肾病和其他类型肾病的比较分析和诊断模型的建立 |
|
论文标题：Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model (膜性肾病和其他类型肾病的比较分析和诊断模型的建立)
期刊：Frontiers of Medicine
作者：Hanyu Zhu（朱晗玉）, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen（陈香美）, Dong Zhang
发表时间：09 Aug 2018
DOI：10.1007/s11684-018-0620-5
微信链接：点击此处阅读微信文章
中国人民解放军总医院肾脏病科朱晗玉和陈香美等在Frontiers of Medicine 发表研究论文《膜性肾病和其他类型肾病的比较分析和诊断模型的建立》（Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model）。
膜性肾病是常见的慢性肾脏病之一，其诊断金标准为肾活检穿刺，但因其有创、操作复杂而未广泛普及。本研究通过Logistic回归分析建立的无创诊断模型可有效诊断膜性肾病，且灵敏度和特异性较高，有广泛的临床应用潜力。
摘 要本研究比较了膜性肾病（MN）和非膜性肾病（non-MN）患者的临床特征，建立了MN的无创诊断模型。纳入MN患者248例和非MN患者550例，Logistic回归分析显示有三个因素（抗PLA2R抗体、IgG和肌酐）与MN独立相关，然后将其用于建立MN诊断模型。ROC曲线证实我们的诊断模型可以有效对MN患者进行诊断，其敏感性为79.9％，特异性为89.4％，曲线下面积为0.917。说明此无创诊断模型可有效诊断MN，有广泛的临床应用潜力。
摘要
This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.
原文信息
标题
Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model
作者
Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang
机构
1. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing 100853, China
2. Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing 100853, China
3. Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Corresponding AuthorsYong Wang and Dong Zhang
Cite this article
Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang. Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model. Front. Med., 2019, 13(5): 618–625https://doi.org/10.1007/s11684-018-0620-5
https://journal.hep.com.cn/fmd/EN/10.1007/s11684-018-0620-5
https://link.springer.com/article/10.1007/s11684-018-0620-5
长按、识别二维码关注Frontiers of Medicine微信公众号
《前沿》系列英文学术期刊
由教育部主管、高等教育出版社主办的《前沿》（Frontiers）系列英文学术期刊，于2006年正式创刊，以网络版和印刷版向全球发行。系列期刊包括基础科学、 、工程技术和人文社会科学四个主题，是我国覆盖学科最广泛的英文学术期刊群，其中13种被SCI收录，其他也被A&HCI、Ei、MEDLINE或相应学科国际权威检索系统收录，具有一定的国际学术影响力。系列期刊采用在线优先出版方式，保证文章以最快速度发表。
中国学术前沿期刊网
http://journal.hep.com.cn/
特别声明：本文转载仅仅是出于传播信息的需要，并不意味着代表本网站观点或证实其内容的真实性；如其他媒体、网站或个人从本网站转载使用，须保留本网站注明的“来源”，并自负版权等法律责任；作者如果不希望被转载或者联系转载稿费等事宜，请与我们接洽。
