来源：Journal of Developmental Biology 发布时间：2026/3/18 15:05:51

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模式生物研究精选：Journal of Developmental Biology（JDB）发表论文一览

期刊名：Journal of Developmental Biology（JDB）

期刊链接：https://www.mdpi.com/journal/jdb

为展示期刊近年来在模式生物研究领域发表的代表性成果，Journal of Developmental Biology (JDB)期刊特别遴选了一系列相关研究论文。该文献清单汇集了发表于2024–20255年的精选研究，涵盖多种经典模式生物体系，包括斑马鱼、果蝇、非洲爪蟾、小鼠、大鼠以及秀丽隐杆线虫等。这些研究从不同层面探讨了发育生物学的重要问题，涉及基因调控、细胞分化、组织稳态、生殖与生育、神经发育以及疾病模型构建等多个方向。

1.“Identification of a Chondrocyte-Specific Enhancer in the Hoxc8 Gene”

Hoxc8基因中软骨细胞特异性增强子的鉴定

文章链接：https://www.mdpi.com/2221-3759/12/1/5

Cormier, S.A.; Kappen, C. Identification of a Chondrocyte-Specific Enhancer in the Hoxc8 Gene.J. Dev. Biol. 2024, 12, 5.https://doi.org/10.3390/jdb12010005

2.“Impact of Stem Cells on Reparative Regeneration in Abdominal and Dorsal Skin in the Rat”

干细胞对大鼠腹部和背侧皮肤修复性再生的影响

文章链接：https://www.mdpi.com/2221-3759/12/1/6

Kananykhina, E.; Elchaninov, A.; Bolshakova, G. Impact of Stem Cells on Reparative Regeneration in Abdominal and Dorsal Skin in the Rat.J. Dev. Biol.2024, 12, 6.https://doi.org/10.3390/jdb12010006

3.”Harderian Gland Development and Degeneration in the Fgf10-Deficient Heterozygous Mouse”

Fgf10缺失杂合小鼠中哈德氏腺的发育与退化

文章链接：https://www.mdpi.com/2221-3759/12/2/16

Ikeda, S.; Sato, K.; Fujita, H.; Ono-Minagi, H.; Miyaishi, S.; Nohno, T.; Ohuchi, H. Harderian Gland Development and Degeneration in the Fgf10-Deficient Heterozygous Mouse.J. Dev. Biol.2024, 12, 16.https://doi.org/10.3390/jdb12020016

4.“Rho-Associated Protein Kinase Activity Is Required for Tissue Homeostasis in theXenopus laevisCiliated Epithelium”

ho相关蛋白激酶活性对非洲爪纤毛上皮组织稳态至关重要

文章链接：https://www.mdpi.com/2221-3759/12/2/17

Khan, F.; Pitstick, L.; Lara, J.; Ventrella, R. Rho-Associated Protein Kinase Activity Is Required for Tissue Homeostasis in the Xenopus laevis Ciliated Epithelium.J. Dev. Biol. 2024, 12, 17.https://doi.org/10.3390/jdb12020017

5.“Lowered GnT-I Activity Decreases Complex-Type N-Glycan Amounts and Results in an Aberrant Primary Motor Neuron Structure in the Spinal Cord”

GnT-I活性降低减少复杂型N-聚糖水平，并导致脊髓初级运动神经元结构异常

文章链接：https://www.mdpi.com/2221-3759/12/3/21

Hatchett, C.J.; Hall, M.K.; Messer, A.R.; Schwalbe, R.A. Lowered GnT-I Activity Decreases Complex-Type N-Glycan Amounts and Results in an Aberrant Primary Motor Neuron Structure in the Spinal Cord.J. Dev. Biol.2024, 12, 21.https://doi.org/10.3390/jdb12030021

6.“Evolution and Spatiotemporal Expression ofankhaandankhbin Zebrafish”

斑马鱼ankha与ankhb基因的进化及其时空表达模式

文章链接：https://www.mdpi.com/2221-3759/12/3/23

Wathuliyadde, N.; Willmore, K.E.; Kelly, G.M. Evolution and Spatiotemporal Expression of ankha and ankhb in Zebrafish.J. Dev. Biol.2024, 12, 23.https://doi.org/10.3390/jdb12030023

7.“Prosaposin/Saposin Expression in the Developing Rat Olfactory and Vomeronasal Epithelia”

Prosaposin/Saposin在发育中大鼠嗅上皮和犁鼻器上皮中的表达

文章链接：https://www.mdpi.com/2221-3759/12/4/29

Kitamura, K.; Saito, K.; Homma, T.; Fuyuki, A.; Onouchi, S.; Saito, S. Prosaposin/Saposin Expression in the Developing Rat Olfactory and Vomeronasal Epithelia.J. Dev. Biol. 2024, 12, 29.https://doi.org/10.3390/jdb12040029

8.“Methyl-Beta-Cyclodextrin Restores Aberrant Bone Morphogenetic Protein 2-Signaling in Bone Marrow Stromal Cells Obtained from Aged C57BL/6 Mice”

甲基-β-环糊精可恢复老龄C57BL/6小鼠骨髓基质细胞中异常的BMP2信号通路

文章链接：https://www.mdpi.com/2221-3759/12/4/30

Halloran, D.; Pandit, V.; Chukwuocha, K.; Nohe, A. Methyl-Beta-Cyclodextrin Restores Aberrant Bone Morphogenetic Protein 2-Signaling in Bone Marrow Stromal Cells Obtained from Aged C57BL/6 Mice.J. Dev. Biol.2024, 12, 30.https://doi.org/10.3390/jdb12040030

9.“The Loss of Tafazzin Transacetylase Activity Is Sufficient to Drive Testicular Infertility”

Tafazzin转乙酰酶活性的缺失可导致睾丸性不育

文章链接：https://www.mdpi.com/2221-3759/12/4/32

Snider, P.L.; Sierra Potchanant, E.A.; Matias, C.; Edwards, D.M.; Brault, J.J.; Conway, S.J. The Loss of Tafazzin Transacetylase Activity Is Sufficient to Drive Testicular Infertility.J. Dev. Biol.2024, 12, 32.https://doi.org/10.3390/jdb12040032

10.“CRISPR/Cas9-Targeted Myostatin Deletion Improves the Myogenic Differentiation Parameters for Muscle-Derived Stem Cells in Mice”

CRISPR/Cas9靶向敲除肌生成抑制素（Myostatin）提升小鼠肌源性干细胞的肌生成分化能力

文章链接：https://www.mdpi.com/2221-3759/13/1/5

Elashry, M.I.; Schneider, V.C.; Heimann, M.; Wenisch, S.; Arnhold, S. CRISPR/Cas9-Targeted Myostatin Deletion Improves the Myogenic Differentiation Parameters for Muscle-Derived Stem Cells in Mice.J. Dev. Biol.2025, 13, 5.https://doi.org/10.3390/jdb13010005

11.“Utilizing C.elegansSpermatogenesis and Fertilization Mutants as a Model for Human Disease”

利用秀丽隐杆线虫（C.elegans）精子发生与受精突变体研究人类疾病

文章链接：https://www.mdpi.com/2221-3759/13/1/4

Perez, S.M.; Augustineli, H.S.; Marcello, M.R. Utilizing C. elegans Spermatogenesis and Fertilization Mutants as a Model for Human Disease.J. Dev. Biol. 2025, 13, 4.https://doi.org/10.3390/jdb13010004

12.“ZebrafishUnga Is Required for Genomic Maintenance upon Genotoxic Stress and Male Fertility”

斑马鱼Unga在基因毒性应激下维持基因组稳定性并影响雄性生育能力

文章链接：https://www.mdpi.com/2221-3759/13/3/32

Kazzazy, L.; Huba, F.; Hausz, B.L.; Mezo, D.; Perey-Simon, V.; Jezsó, B.; Seddik, A.; Marinovic, Z.; Tóth, J.; Békési, A.; et al. Zebrafish Unga Is Required for Genomic Maintenance upon Genotoxic Stress and Male Fertility. J. Dev. Biol. 2025, 13, 32. https://doi.org/10.3390/jdb13030032

13.“GLP-1-Mediated Pregnancy and Neonatal Complications in Mice”

GLP-1介导的小鼠妊娠及新生期并发症

文章链接：https://www.mdpi.com/2221-3759/13/3/29

Ramamoorthy, R.; Carden, A.K.; Hussain, H.; Druyan, B.Z.; Chen, P.P.; Hajjar, R.; Fernandez, C.; Elumalai, N.; Rashed, A.B.; Young, K.; et al. GLP-1-Mediated Pregnancy and Neonatal Complications in Mice.J. Dev. Biol.2025, 13, 29.https://doi.org/10.3390/jdb13030029

14.“Cannabinoid Receptor 1 Regulates Zebrafish Renal Multiciliated Cell Development via cAMP Signaling”

大麻素受体1通过cAMP信号通路调控斑马鱼肾脏多纤毛细胞的发育

文章链接：https://www.mdpi.com/2221-3759/13/2/20

Nguyen, T.K.; Baker, S.; Angtuaco, J.; Arceri, L.; Kaczor, S.; Fitzsimonds, B.; Hawkins, M.R.; Wingert, R.A. Cannabinoid Receptor 1 Regulates Zebrafish Renal Multiciliated Cell Development via cAMP Signaling.J. Dev. Biol. 2025, 13, 20.https://doi.org/10.3390/jdb13020020

15.“Drosophila Males Differentially Express Small Proteins Regulating Stem Cell Division Frequency in Response to Mating”

果蝇雄性通过差异表达小蛋白响应交配行为并调控干细胞分裂频率

文章链接：https://www.mdpi.com/2221-3759/13/3/21

Malpe, M.S.; McSwain, L.F.; Aston, H.M.; Kudyba, K.A.; Ng, C.; Wright, M.P.; Schulz, C. Drosophila Males Differentially Express Small Proteins Regulating Stem Cell Division Frequency in Response to Mating.J. Dev. Biol. 2025, 13, 21.https://doi.org/10.3390/jdb13030021

16.“Investigating Psychopharmaceutical Effects on Early Vertebrate Development Using a Zebrafish Model System”

利用斑马鱼模型研究精神类药物对脊椎动物早期发育的影响

文章链接：https://www.mdpi.com/2221-3759/13/3/22

Zimmerman, N.; Marta, A.; Baker, C.; Korade, Z.; Mirnics, K.; Shibata, A. Investigating Psychopharmaceutical Effects on Early Vertebrate Development Using a Zebrafish Model System.J. Dev. Biol.2025, 13, 22.https://doi.org/10.3390/jdb13030022

17.“Deletion of Ptpmt1 by αMHC-Cre in Mice Results in Left Ventricular Non-Compaction”

在小鼠中通过αMHC-Cre介导敲除Ptpmt1导致左心室心肌致密化不全

文章链接：https://www.mdpi.com/2221-3759/13/3/25

Huang, L.; Cao, M.; Zhu, X.; Li, N.; Huang, C.; Ouyang, K.; Chen, Z. Deletion of Ptpmt1 by αMHC-Cre in Mice Results in Left Ventricular Non-Compaction.J. Dev. Biol. 2025, 13, 25.https://doi.org/10.3390/jdb13030025

18.“Identification and Characterization of Static Craniofacial Defects in Pre-Metamorphic Xenopus laevis Tadpoles”

非洲爪蟾变态前蝌蚪颅面结构缺陷的鉴定与特征分析

文章链接：https://www.mdpi.com/2221-3759/13/3/26

Jones, E.; Fonticella, J.M.; McLaughlin, K.A. Identification and Characterization of Static Craniofacial Defects in Pre-Metamorphic Xenopus laevis Tadpoles.J. Dev. Biol. 2025, 13, 26.https://doi.org/10.3390/jdb13030026

19.“Drosophila COMPASS Complex Subunits Set1 and Ash2 Are Required for Oocyte Determination and Maintenance of the Synaptonemal Complex”

果蝇COMPASS复合体亚基Set1和Ash2对卵母细胞命运决定及联会复合体维持至关重要

https://www.mdpi.com/2221-3759/13/3/30

MDPI引用格式：Cabrita, B.; Enyioko, M.; Martinho, R.G. Drosophila COMPASS Complex Subunits Set1 and Ash2 Are Required for Oocyte Determination and Maintenance of the Synaptonemal Complex.J. Dev. Biol. 2025, 13, 30.https://doi.org/10.3390/jdb13030030

20.“A Supra-Physiological Dose of 2-Hydroxyestradiol Impairs Meiotic Progression and Developmental Competence of Mouse Antral Oocytes”

超生理剂量的2-羟基雌二醇损害小鼠窦卵泡卵母细胞的减数分裂进程及发育能力

文章链接：https://www.mdpi.com/2221-3759/13/4/37

Merico, V.; Rebuzzini, P.; Zanoni, M.; Zuccotti, M.; Garagna, S. A Supra-Physiological Dose of 2-Hydroxyestradiol Impairs Meiotic Progression and Developmental Competence of Mouse Antral Oocytes.J. Dev. Biol. 2025, 13, 37.https://doi.org/10.3390/jdb13040037

21.“Dynamic Alterations in Testicular Autophagy in Prepubertal Mice”

青春期前小鼠睾丸自噬的动态变化

文章链接：https://www.mdpi.com/2221-3759/13/4/42

Zhang, D.; Pang, X.; Yan, Z.; Dong, W.; Fang, Z.; Yang, J.; Wang, Y.; Xue, L.; Zhang, J.; Xue, C.; et al. Dynamic Alterations in Testicular Autophagy in Prepubertal Mice.J. Dev. Biol. 2025, 13, 42.https://doi.org/10.3390/jdb13040042

22.“A Zebrafish Seizure Model of cblX Syndrome Reveals a Dose-Dependent Response to mTor Inhibition”

斑马鱼cblX综合征癫痫模型揭示对mTOR抑制的剂量依赖性反应

文章链接：https://www.mdpi.com/2221-3759/14/1/2

Gil, C.B.; Paz, D.; Pinales, B.E.; Castro, V.L.; Perucho, C.E.; Gonzales, A.; Francia, G.; Masenga, S.K.; Hinton, A., Jr.; Quintana, A.M. A Zebrafish Seizure Model of cblX Syndrome Reveals a Dose-Dependent Response to mTor Inhibition.J. Dev. Biol. 2026, 14, 2.https://doi.org/10.3390/jdb1401000

JDB期刊介绍

主编：Simon J. Conway, Indiana University School of Medicine, USA

期刊主要发表关于分子、细胞、组织、器官和整个生物体层面的多细胞生物发育的相关文章。

2024 Impact Factor	2.5
2024 CiteScore	4.5
Time to First Decision	27.1 Days
Acceptance to Publication	5. 6 Days