近日，美国宾夕法尼亚大学Edward E. Morrisey等研究人员合作发现，病毒感染后肺部再生的纵向单细胞谱系揭示持续的损伤相关细胞状态。相关论文于2025年1月15日在线发表于国际学术期刊《细胞—干细胞》。

据了解，肺部在损伤后进行功能性再生，需要在肺泡微环境内协调一系列复杂的细胞行为。

附：英文原文

Title: Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states

Author: Terren K. Niethamer, Joseph D. Planer, Michael P. Morley, Apoorva Babu, Gan Zhao, Maria C. Basil, Edward Cantu, David B. Frank, Joshua M. Diamond, Ana N. Nottingham, Shanru Li, Arnav Sharma, Hannah Hallquist, Lillian I. Levin, Su Zhou, Andrew E. Vaughan, Edward E. Morrisey

Issue&Volume: 2025-01-15

Abstract: Functional regeneration of the lung’s gas exchange surface following injury requires the coordination of a complex series of cell behaviors within the alveolar niche. Using single-cell transcriptomics combined with lineage tracing of proliferating progenitors, we examined mouse lung regeneration after influenza injury, demonstrating an asynchronously phased response across different cellular compartments. This longitudinal atlas of injury responses has produced a catalog of transient and persistent transcriptional alterations in cells as they transit across axes of differentiation. These cell states include an injury-induced capillary endothelial cell (iCAP) that arises after injury, persists indefinitely, and shares hallmarks with developing lung endothelium and endothelial aberrations found in degenerative human lung diseases. This dataset provides a foundational resource to understand the complexity of cellular and molecular responses to injury and correlations to responses found in human development and disease.

DOI: 10.1016/j.stem.2024.12.002

Source: https://www.cell.com/cell-stem-cell/abstract/S1934-5909(24)00441-7