美国哈佛大学Wendy S. Garrett课题组发现，饮食可通过翻译后修饰影响小鼠肠道微生物蛋白质组，从而调节肾功能。相关论文于2020年9月18日发表在《科学》杂志上。

Title: Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function

Author: Lior Lobel, Y. Grace Cao, Kathrin Fenn, Jonathan N. Glickman, Wendy S. Garrett

Issue&Volume: 2020/09/18

Abstract: Associations between chronic kidney disease (CKD) and the gut microbiota have been postulated, yet questions remain about the underlying mechanisms. In humans, dietary protein increases gut bacterial production of hydrogen sulfide (H2S), indole, and indoxyl sulfate. The latter are uremic toxins, and H2S has diverse physiological functions, some of which are mediated by posttranslational modification. In a mouse model of CKD, we found that a high sulfur amino acid–containing diet resulted in posttranslationally modified microbial tryptophanase activity. This reduced uremic toxin–producing activity and ameliorated progression to CKD in the mice. Thus, diet can tune microbiota function to support healthy host physiology through posttranslational modification without altering microbial community composition.

DOI: 10.1126/science.abb3763

Source: https://science.sciencemag.org/content/369/6510/1518