直播时间：2023年4月28日（周五）20:00-21:30

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北京时间2023年4月28日晚八点，iCANX Talks 第141期将在iCANX平台上线！本期我们邀请到东京大学Beomjoon Kim教授进行分享医用生物分子传输微针系统！更多精彩，敬请期待！

【直播介绍】

Beomjoon Kim

The University of Tokyo

Biomolecular Needling Systems for Medicals

【Abstract】

Recently, in the transdermal drug delivery methods, the microneedle-mediated drug delivery system (DDS) has been developed to replace the hypodermic injection-mediated DDS, to provide painless self-administration of biological drug with patient friendly manner. Dissoluble microneedles are attracting many attentions as it has several advantages such as no needle-related risks. We have developed new fabrication methods for biodegradable microneedles array patches (MAPs), which are different with the conventional fabrication ones, such as stepwise casting method. Here, new transdermal drug delivery system by using dissoluble micro needle patch will be introduced. We also develop several aspects of bio-sensors components to accomplish portable Point-of-Care diagnostic devices, which are disposal, user-friendly, low-cost, and highly sensitive.

近年来，基于微针的透皮给药系统已被开发出来，以取代皮下注射的给药方式，为患者提供了一种无痛友好的自我给药方法，其中，可溶性微针因其无针头相关风险等优势而备受关注。不同于传统制备方法，我们开发了生物可降解微针阵列贴片的逐步铸模法等新型制备技术，本次演讲将介绍一种基于可溶性微针贴片的新型透皮给药系统。同时微针还可用于生物信息检测，我们开发了多种生物传感器，并与微针集成为便携式即时诊断器件，具有易于使用及处理、低成本和高灵敏度等诸多优点。

We fabricated porous microneedle on a paper substrate to develop a novel platform for direct integration of sensors. The device painlessly monitors fluid in the skin within seconds. Anyone can use the disposable patch without training, making it highly practical. Additionally, fabrication is easy, low cost, and the glucose sensor can be swapped for other paper-based sensors that monitor other important biomarkers.

通过在纸基板上制备多孔微针，我们开发出一种新型传感器直接集成平台，能够在几秒钟内无痛检测皮肤内的液体。任何人都可以不经培训便能使用该一次性贴片，因此非常实用。此外，该贴片制造工艺简单、成本低，并且葡萄糖传感器可以替换为其它基于纸材的传感器，以监测其它重要的生物标志物。

【BIOGRAPHY】

Beomjoon Kim is a Professor of Institute of Industrial Science, the University of Tokyo, Japan. Also, he is currently a director of LIMMS-KIKO, a director of CREMeB (Center for Research on Engineering in Medicine and Biology), and in charge as a chair of corporate sponsored research division of “Virological Medicine”, at I.I.S., the University of Tokyo. He received his B.E. degree from Seoul National University, Dept. of Mechanical Design and Production Eng., Korea, in 1993, and M.S., Ph.D. in Precision Engineering, from the University of Tokyo, Japan, in 1995 and 1998, respectively. He was a CNRS Associate Researcher in LPMO, Besancon, France (1998-99), and worked in MESA+ Research Institute, University of Twente (1999-2000).

金範埈教授就职于日本东京大学生产技术研究所，同时担任LIMMS-KIKO和CREMeB（医学和生物学工程研究中心）董事、“病毒医学”研究部门主席。在教育背景方面，金教授于1993年在韩国首尔国立大学机械设计与制造工程系获得学士学位，1995年和1998年分别获得日本东京大学精密工学系硕士和博士学位。在工作经历方面，金教授于1998-1999年在法国贝桑松物理与计量实验室（LPMO）担任副研究员，1999-2000年在荷兰特文特大学MESA+纳米技术研究所工作。

He was an Associate Professor in the Univ. of Tokyo (2000-2013), and was a co-director at the CIRMM/CNRS Paris office (2001-2003). He investigates several aspects of bio-sensors components to accomplish portable Point-of-Care diagnostic devices, which are disposal, user-friendly, low-cost, and highly sensitive. Moreover, he is interested to develop self-powered, energy harvesting micro sensors as well as smart monitoring system. Recently, main research topic is focused to study on new transdermal drug delivery system by using dissoluble micro needle patch. He has published 113 peer reviewed journal papers, 216 international conference papers, 204 domestic conference papers as well as tens of patents, books publications so far.

2000-2013年担任东京大学副教授，其中2001-2003年期间同时担任CIRMM/CNRS巴黎办公室联席主任，2014年至今担任东京大学教授。在科学研究方面，金教授研制出集成了微针与生物传感器的便携式即时诊断器件，具有易于使用及处理、低成本和高灵敏度等诸多优点；此外研制了一系列通过能量收集实现自供能的微型传感器以及智能监测系统。近年来的主要研究方向是基于可溶性微针贴片开发新型透皮给药系统。金教授目前已发表期刊论文113篇，国际会议论文216篇，日本国内会议论文204篇，授权发明专利十余项，出版专著十余部。